Mac 10.9.4 Enable Trim

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Enable TRIM on non-Apple SSDs in OS X

NOTE: This is tested on the versions mentioned in the title, and NOT earlier or later versions. YMMV.
Run the following commands in Terminal…
Backup the original driver:

sudo cp /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage-backup

Modify the driver (choose only one of the following lines, based on the version):

# 10.9.4
sudo perl -pi -e 's|(^\x00{1,20})[^\x00]{9}(\x00{1,20}\x54)|$1\x00\x00\x00\x00\x00\x00\x00\x00\x00$2|sg' /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage
# 10.8.3 to 10.9.3
sudo perl -pi -e 's|(\x52\x6F\x74\x61\x74\x69\x6F\x6E\x61\x6C\x00{1,20})[^\x00]{9}(\x00{1,20}\x54)|$1\x00\x00\x00\x00\x00\x00\x00\x00\x00$2|sg' /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage
# 10.7.5, 10.8.1, 10.8.2
sudo perl -pi -e 's|(\x52\x6F\x74\x61\x74\x69\x6F\x6E\x61\x6C\x00{1,20})[^\x00]{9}(\x00{1,20}\x4D)|$1\x00\x00\x00\x00\x00\x00\x00\x00\x00$2|sg' /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage

Run these commands in succession to clear the system caches to enable OS X to pick up the modified driver:

sudo kextcache -system-prelinked-kernel
sudo kextcache -system-caches
sudo touch /System/Library/Extensions/

Restart the Mac.
 
From:
https://gist.github.com/clarencesong/3768688